Product Data Sheet Caution: Not Fully Tested. for Research Purposes Only
نویسندگان
چکیده
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. SB-705498 potently inhibits capsaicin-induced activation of human TRPV1 expressed in 1321N1 cells or HEK293 cells with apparent pKi of 7.5 or 7.6, respectively. Coapplication of 100 nM SB-705498 rapidly, completely and reversibly inhibits hTRPV1 expressed in HEK293 cells. Compared with placebo, SB-705498 reduced the area of capsaicin-evoked flare (P=0.0047). The heat pain threshold on non-sensitised skin was elevated following SB-705498 (estimated difference from placebo [95% confidence intervals]: 1.3 degrees C [0.07,2.53], P=0.019). Following capsaicin sensitisation, the heat pain threshold and tolerance were
منابع مشابه
Product Data Sheet Caution: Not Fully Tested. for Research Purposes Only
LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian central nervous system (CNS). Recent evidence has shown that in addition to modulating fast synaptic plasticity and memory processes, AMPA receptor potentiators alter down...
متن کاملA Methodology for Product Performance Analysis under Effects of Multi-Physical Phenomena
Due to the development of science and technology, the computer has become a useful tool for supporting engineering activities in product design. Many computer aided tools such as CAD/CAM, product data management (PDM), product life cycle assessment (PLA), etc., have been popularly used in industry for reducing product development lead-time and increasing total product quality. However, the nume...
متن کاملبررسی نحوه اجرای روش هم اطاقی مادر و نوزاد پس از زایمان در زایشگاهها و بیمارستانهای آموزشی دانشگاههای علوم پزشکی شهر تهران
In this descriptive study, we investigated how mother and infant rooming method after delivery are implementing in academic hospitals of Tehran University of Medical Sciences in 1993. In this research, fifteen wards include post delivery ward, surgical ward that mothers after cesarean section hospitalized in them and jointed ward that mothers who underwent cesarean section and normal vaginal ...
متن کاملSynthesis of porous CdO sheet-like nanostructure based on soft template model and its application in dye pollutants adsorption
In this work, the synthesis of porous structure of cadmium oxide with multilayered sheet-like morphology in nano-meter size using adipic acid as soft template by solvothermal/thermal decomposition process is reported. Chemical analyses exhibited that the formation of porous sheet-like structure is originated from bidentate coordination mode of adipate units to Cd-center. It was found that the c...
متن کاملSynthesis of porous CdO sheet-like nanostructure based on soft template model and its application in dye pollutants adsorption
In this work, the synthesis of porous structure of cadmium oxide with multilayered sheet-like morphology in nano-meter size using adipic acid as soft template by solvothermal/thermal decomposition process is reported. Chemical analyses exhibited that the formation of porous sheet-like structure is originated from bidentate coordination mode of adipate units to Cd-center. It was found that the c...
متن کامل